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涓撴敞鍗曠粏鑳?yōu)涓庡井閲忚泲鐧借川缁勫妫嫻嬫妧鏈紝涓虹敓鍛界瀛︺佽嵂鐗╃爺鍙戜笌涓村簥鍖誨鎻愪緵鍒涙柊瑙ｅ喅鏂規(guī)銆備互鎶鏈垱鏂頒負(fù)寮曟搸錛屼互宸ョ▼钀藉湴涓哄鍚戯紝鎺ㄥ姩铔嬬櫧璐ㄧ粍瀛﹂潻鏂扮敓鐗╁璁ょ煡錛屽紩棰嗗尰瀛﹀疄璺墊柊紿佺牬銆?
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姘寸唺璧勮
2025-05-12
灞曚細(xì)鎶ラ亾涓ㄧ涔?jié)灞婁笢鍖椾笁鐪佷竴鍖哄厤鐤瀛︽湳鐮旇浼?
2025騫?鏈?0鏃ワ紝絎節(jié)灞婁笢鍖椾笁鐪佷竴鍖哄厤鐤瀛︽湳鐮旇浼?xì)浜庢矆闃冲寳绾﹀缁存櫙鍥介檯澶ч厭搴椾笐謯炲Q屾按鐔婄鎶鍙楅個(gè)鍙傚姞姝ゆ灞曡錛屽睍鍑鴻嚜涓葷爺鍙戠殑鍗曠粏鑳?yōu)澶氶噸铔嬬櫧鍒嗘瀽绯痪l焟WB-X2鍙?qiáng)閰嶅scWestern 璇曞墏鐩掞紝浠ュ強(qiáng)鏈勾搴﹀彂甯冪殑鏂頒駭鍝侊細(xì)鑶滅壒寮傛у娉屼綋瀵岄泦璇曞墏鐩掋乀SA澶氳壊鍏嶇柅鑽у厜鏌撹壊璇曞墏鐩掋?
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2025-04-11
銆愭柊鍝佸彂甯冦戞按鐔婄鎶 ExoMESS鈩?鑶滅壒寮傛у娉屼綋瀵岄泦璇曞墏鐩?
姘寸唺縐戞妧鎺ㄥ嚭涓嬈鵑潻鍛芥х殑澶栨硨浣撳瘜闆嗕駭鍝佲斺擡xoMESS鈩?鑶滅壒寮傛у娉屼綋瀵岄泦璇曞墏鐩掋傚熀浜庣嫭瀹禡ESS鎶鏈紝ExoMESS鈩㈣В鍐充簡澶栨硨浣撳瘜闆嗙殑鎶鏈毦棰樸?
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2023-09-21
絀洪棿浠ｈ阿緇勫+铔嬬櫧璐ㄧ粍瀛︽帰絀惰偤鑵虹檶娌葷枟鐨勬柊闈剁偣
鐧屽熀鍥燢RAS鏄疪AS鍩哄洜浜氬鏃忕殑涓鍛橈紝RAS鍩哄洜閫氬父鍦ㄤ漢綾葷檶鐥囦腑鍙戠敓紿佸彉錛屽寘鎷偤鑵虹檶銆俁AS鍩哄洜緙栫爜鑶滃畾浣嶇殑G铔嬬櫧錛屾槸鍑犱釜淇″彿綰ц仈鐨勭粍鎴愰儴鍒嗭紝鍖呮嫭Raf-MEK-ERK淇″彿杞閫氳礬銆侹RAS寮曡搗鐨勪唬璋㈠彉鍖栬璁や負(fù)鍦ㄧ檶鐥囩殑澧炴畺鍜屽瓨?gòu)z諱腑璧風(fēng)潃鑷沖叧閲嶈鐨勪綔鐢紝浣咾RAS瀵硅偤鑵虹檶鑴傝偑鐢熸垚鐨勮皟鎺т綔鐢ㄥ皻涓嶆槑紜侻SI浣滀負(fù)涓縐嶅伐鍏峰凡緇忚騫挎硾鐮旂┒錛屽畠鍙互灝嗙檶緇勭粐涓庢甯哥粍緇囧尯鍒嗗紑鏉ワ紝騫跺鍚勭鑲跨槫榪涜鍒嗙被銆傚湪鏈爺絀朵腑錛屼綔鑰呬嬌鐢ㄨВ鍚哥數(shù)鍠烽浘鐢電璐ㄨ氨鎴愬儚(DESI-MSI)鍒嗘瀽kras椹卞姩鐨勮偤浠ｈ阿錛屽茍緇撳悎鍩哄洜琛ㄨ揪鍒嗘瀽銆佺撼綾崇駭铔嬬櫧璐ㄧ粍瀛﹀拰MSI鍒嗘瀽鏉ョ爺絀惰偤鐧屼腑KRAS紿佸彉鍜岃剛璐ㄧ壒寰佷箣闂寸殑鍏崇郴銆傝瘉瀹炰簡鐢ㄦ不鐤楀墏闃繪柇FASN鍙互闃叉kras鐩稿叧鐨勮偤鐧岀粏鑳?yōu)澧瀸D栥?
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2023-09-21
鍖誨涓鍖洪《鍒婏細(xì)闈跺悜浠ｈ阿緇勫鎺㈢┒鏀摼姘ㄥ熀閰哥紦瑙ｅ笗閲戞．灝忛紶鐨勫彂鐥?
2022騫?鏈堬紝鍝堝皵婊ㄥ尰縐戝ぇ瀛﹂檮灞炲尰闄㈠涓借姮鏁欐巿璇鵑緇勶紙涓浣滐細(xì)闂弽鐝嶏級(jí)鍦˙rain Behavior and Immunity鏈熷垔鍙戣〃浜嗛涓?鈥淩ole of gut microbiota-derived branched-chain amino acids in the pathogenesis of Parkinson’s disease: An animal study 鈥濈殑鐮旂┒鎴愭灉錛岄氳繃姘旂浉鑹茶氨-璐ㄨ氨娉曘佸厤鐤銆丟C-MS闈跺悜浠ｈ阿緇勫銆佸井鐢熺墿16S rRNA鍩哄洜嫻嬪簭鐮旂┒鏂規(guī)硶錛屽彂鐜頒簡鑲犻亾寰敓鐗╃兢浠ｈ阿鐨勫姩鎬佸彉鍖栫壒寰侊紝鎺㈢┒浜咮CAAs璋冭妭PD鐨勬満鐞嗭紝鎻忕粯浜咮CAAs褰卞搷鑲犻亾寰敓鐗╃兢鍜岀値鐥囧洜瀛愬浘璋憋紝涓哄笗閲戞．鐤劇梾鐨勬繁鍏ョ爺絀舵彁渚涗簡鐞嗚渚濇嵁銆?
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